Vitamin D research continues to attract worldwide interest, with a large and diverse community of researchers across various facets of human health. In contrast to the 1980s, and the early Vitamin D Workshops, that were defined by seminal advances in our understanding of the basic molecular endocrinology of vitamin D, current vitamin D research reflects much broader research perspectives. Supplementation trials, systematic reviews, genome-wide association studies, OMICs analyses, new mouse models and assay advances have all resulted in recent high-profile publications that have kept vitamin D research in the public eye. Despite this, funding constraints and shifts in research priorities suggest a more challenging future for vitamin D groups across the globe. This session will highlight areas of vitamin D research that show promise for future studies – notably aspects of vitamin D that have been less well-covered elsewhere at the current Workshop. Topics to be covered will include: Current views on Mendelian Randomisation as a tool for defining possible causative effects of vitamin D; The role of vitamin D in acute/intensive care, with burn injury patients as an example; The continuing evolution of vitamin D metabolite analytical techniques; Entirely new facets of vitamin D physiology, with vitamin D binding protein-diabetes interactions as an example. The aim of the presentation will be to underline the persistent innovation within the field of vitamin D, providing an optimistic outlook for future research.